Thumpalumpacus
Major
If you didn't have to add additional equipment, the first solution would be adding ballast before a structural mod.
Not being too conversant with the equipment weights, I'd think that extending the rear of the nacelle to accommodate the RIO -- and perhaps a larger radar than the pod-mount carried by the P-38M -- I was thinking that a plug installed forward of the cockpit to put the weight of guns and/or ammo would serve to counterbalance.
Then again, we could simply take advice about the P-39 and move the radio?
Bottom line is that if this project is taken in hand in early 1942, I don't doubt that by mid-1943 a flying solution could hit the assembly lines and be issued to squadrons for work-ups.