OK, I'll explain. For a full technical explanation, go to Tony Williams' website. Short answer, as you go up into larger and larger cartridges, the variablility in burning time for the propellant in that cartridge makes the exit time for the shell from the barrel more and more unpredictable, which means that there is a real danger that sooner or later one of the shells could hit the propeller.
Erm, as long as the round goes bang on cue and doesn't loose like 100 m/s or so in MV then I'm quite sure it wouldn't matter to a gun like the Mk103.