This is my first one. The main difference is the parts are cemented together with 'super'-glue rather than the usual polysterene cement.
The resin parts seem to cut, shave and sand in a similar fashion to the usual plastic, and painting seems to be working the same.
On the downside: the parts are not quite so crisp, there are more unwanted lumps and bumps to get rid off, and some parts seem to be distorted which is not easy to bend back as the resin parts aren't as flexible as plastic. The kit doesn't 'fall' together like the usual major die cast plastic kit as there aren't things like locating holes etc for parts to go together.
All in all, it'll be a lot more work than a proper plastic kit, but is do-able, and worth it if you want the more exotic subjects that only resin kit makers do.