This is an interesting debate because it begs the question, most devastating or most effective.
The Pappy Gunn modified B-25s had a crucial impact on the Battle of Bismark Sea when the Japanese tried to move reinforcements to New Gunea and then made major contributions from that time forward in missions from sinking troop transports and freighters with water line stikes from 10-14 .50's plus skip bombing with 250 to 500 ponders - or laying parafrags.
But wouyld it have survived in ETO? As Erich mentioned the 355th had the best total of German a/c destroyed on the ground and pioneered strafing of German airfields - but lost 92+ to German flak - twice as many as lost battling German fighters.. Itwas strafing at 350-400mph in shallow dives, quick strikes - one group to shoot up flak batteries - the rest to hammer the a/c.
B-25s, Beaufighters, etc would not do well in these missions.. Tempest, P-47s and Mustangs did this well and Mustangs did the most on German airfields and deep transportation strikes but more vulnerable..
If I was making a living strafing, deep in heavily defended areas, it would be in a Jug - the key is range here coupled with heavy firepower and relative survivability against both flak and fighters.
The A-26 takes top honors of the twin engine attack bombers, I believe