The fuel-injected derivative of the Kinsei became available in late 1941. It reached aircraft in late 1942, such as the Ki-46 III. Jiro Horikoshi mentioned in his book that a 1,500 HP Zero could have made its way into combat by the Summer of 1943, enough to slow the progression of the war.
There was a lot more than fuel injection that made the Kinsei 60 series capable for 1500 HP (and a bit more). Like the water-alcohol injection (curiously enough, not fitted on the Ki-100 in 1945?), and the bigger supercharger - 12.6 in impeller vs. the 11.4 in on the 50 series.
Granted, the fully-rated Kinsei 62 on a Zero from early 1943 on would've made the life ... interesting to the Allied pilots & crewmen.