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There is little doubt in my mind that the 109 would be to much for the Zero.
Normally I stay out of debates like this as I am a huge Bf-109 fan. But to say the 109 would be to much for the zero. I wouldn't go that far. The Australian's and the British had a ton of losses in the pacific fighting the zero with spitfires.
Maneuverability and range alone goes to the Zero. Just for the shear fun of it they could stay just out of range and wait till they run out of gas and then smoke them landing or crashing.
Armor goes to the Bf-109 hands down. Speed goes to a Bf-109E-3 at around 348 mph depending on source and a A6M3B or model 21 goes at around 331 mph. Difference of around 17 mph. At which time both came out around the same time.
Fire power I would rate to be pretty much even. Both had cannon and machine gun's. Although in the long run I would go with the Bf-109 machine guns.
Basically under rating an enemy especially one with world wide respect such as the zero should never be treated lightly. Both the zero and the Bf-109 were well respected by the pilots that flew against them. To treat them any other way is to invite a very quick death in combat as many allied pilots found out.
Stay above 300 mph, it's that simple...Yes I do tend to think the Bf-109E would beat the Zero but it would require a great deal of effort to win...
All the A6M pilot would have to do is stay out of the 109's sights and wait for it to run out of gas
Didn't the Allies believe the Hein (Tony) was a licence built `09?
...load og MG 151/20...