I think one major mistake in WW2 was Heinkel NOT following Avro's example and replacing the coupled engines of the He 177 with 4 individual engines as in the Manchester - Lancaster.
This would have yielded a strategic bomber that actually worked for the Luftwaffe. Also, who's idea was it to make the He 177 a dive bomber anyway?
This would have yielded a strategic bomber that actually worked for the Luftwaffe. Also, who's idea was it to make the He 177 a dive bomber anyway?