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Not really. The Bf 109 was, in its day, a very high performance fighter, the later versions just as good as the P51 Mustang. If you use the search engine you'll find that this has been discussed at length many times on the forum. It was only the level of attrition, poor training of Luftwaffe pilots and overwhelming numerical superiority that tipped the balance.
As far as I'm aware (and I admit I'm no expert on the P51) the original design by Schmued was hideously overweight and it was only with help from studying British design and manufacturing that an improved airframe could result. And there's the small matter of the Rolls Royce Merlin engine...